Simulation of immune-reaction to biomaterials.

Aim of the project: the objective of this project is to build a digital twin of the inflammatory response and fibrotic process in a foreign body reaction. With such a system validated, it will be possible to monitor continuously the evolution of the reaction by monitoring a limited set of parameters in only few timepoints.

Methodology: Different strategies will be compared: ordinary differential equations models and agent based models. Public database and literature searches will be performed to compile all relevant pathways and their reaction rates. Special care will be used to integrate mechano-transduction pathways together with the cytokines signaling related ones.

Requirements:Master degree in Physics or Biomedical Engineering and high motivation to work in an interdisciplinary environment; fluent English skills, both written and spoken; background in system biology; good programming skills in Matlab and Python.

The candidate will work in a multidisciplinary environment between the Physics, Biotechnology and Experimental Medicine departments and introduced to an international collaboration with groups working on the same subject at the Tel Aviv University (TAU, IL) and at FORTH (Crete, GR).

please contact Giuseppe Chirico or Luca Presotto at unimib.