Giulio Cerullo

Giulio Cerullo is a Full Professor with the Physics Department, Politecnico di Milano, where he is leading the ultrafast optics and
spectroscopy group.

Prof. Cerullo’s research activity covers a broad area known as “Ultrafast Optical Science”, and concerns on the one hand
pushing our capabilities to generate and manipulate ultrashort light pulses, and on the other hand using such pulses to capture the dynamics of ultrafast events in molecular and solid-state systems.

He is the recipient of a 2011 ERC Advanced Grant (project STRATUS).

His role in the project will be: Scientific coordination of the ultrafast laser setup and non-linear polymerization experiments.

More info here.

Manuela Teresa Raimondi

Manuela Raimondi is full professor of Bioengineering at Politecnico di Milano since 2009.

She and her group develop frontier tools for research in biology, such as nanoengineered stem cell niches, microfluidic
bioreactors and miniaturised windows for imaging in vivo.

She has been recipient, among others, of an ERC grant and is founder of a start-up bio-engineering company.

Her role in the project will be: coordination of the bioengineering team; scientific supervision of the work concerning device design and development, validation in vitro and in vivo on chicken embryos.

Other info here.

Núria Coderch

First time in FET.

Núria holds a PhD in Pharmacy and a long academic research experience.
Broad scientific background in the area of microbiology and pharmacy and 10+ years as Regulatory Affairs Director in Asphalion.

Nuria is a specialist in the regulatory field for Biological, Biotechnological, and Advanced Therapy Medicinal Products having managed and conducted successful Scientific Advice Procedures, IMPDs, CTAs, as well as collaboration in compilation of Centralised Procedure Applications.

Great experience in Regulatory procedures during development, medical and CMC scientific writing including ATMPs and Biologicals, technical writing for registration dossiers, IMPDs, IBs, CTAs, FDA procedures and Pharmacovigilance

More info here.

Francesca Granucci

Francesca Granucci (PhD in Pharmacology and Toxicology in 1996) is currently full professor of Immunology and General Pathology at the Department of Biotechnology and Biosciences, University of Milano-Bicocca and chief of the Innate Immunity lab at INGM, National Institute of Molecular Genetics.

In 2012 she obtained the EFIS-EJI Ita Askonas prize as best female group leader in immunology and in 2019 the IUBMB Jubilee Lecturer medal. Her role in the project will be: implant protocols for the IN2SIGHT chip and mice breed bearing multiple fluorescent immune cells.

More info here.

Giuseppe Chirico

Giuseppe Chirico graduated in Physics, PhD in Biophysics, is full professor of Applied Physics, at the Università degli Studi di Milano-Bicocca, Dep. of Physics. GC is the PI of the Laboratory for Advanced Bio-Spectroscopy (LABS) financed by the Università di Milano-Bicocca.
His scientific background is in photon- and fluorescence correlation spectroscopy, single molecule fluorescence spectroscopy for biomolecules characterization in vitro and fluorescence two-photon excitation and second harmonic generation microscopy applied to in-vivo imaging of tissues. G.C., then at the Università degli studi di Genova (Genoa, I), developed and run the first facility for non-linear excitation microscopy in Italy from 1996 to 1999. G.C. has previously spent research periods as postdoc or visiting researcher at the EMBL Grenoble outstation (1990), at the DKFZ in Heidelberg (1995) and at the Laboratory for Fluorescence Dynamics (Urbana-Champaign, IL, in 1996). He has been recently appointed by the Italian Ministry of Research and Technology as member of the committee for the national habilitation in Applied Physics. GC is member of SPIE (International Society for Optics and Photonics Engineering), the Italian Society for Pure and Applied Biophysics and the Italian Physics Society, editor of PLOSONE, of Biomedical engineering Online, author/co-author of more than 160 publications on scientific journals: H factor = 29, total citations 2800.

His role in the project will be: coordination and management; development of the scanning system and adaptive optics protocols; imaging of labeled cells in the IN2SIGHT; fluidodynamic studies in the nude chip implanted in the micro – fluidic device

More info here.

Hellmut Augustin

DVM, PhD, is an experimental pathologist with 30 years of experience in vascular biology research.
HGA head the Joint Research Division Vascular Biology within the DKFZ-ZMBH-Alliance and Heidelberg University (Mannheim Campus).

He is leading a multidisciplinary research group exploring vascular biology from different perspectives, including angiogenesis and vascular differentiation, tumor progression and metastasis as well as vascular signaling and developmental vascular biology.

He has done pioneering work in the establishment of novel endothelial cell differentiation and angiogenesis assays which will significantly contribute to In2SIght.

More info here.

Uri Nevo

Prof. Uri Nevo is chairman of the Department of Biomedical Engineering (BME) in Tel Aviv University.
Prof. Nevo did all his academic degrees in the School of Physics and Astronomy in Tel Aviv University.
He served as a Fulbright fellow performing his postdoctoral research in the NIH, in Bethesda, MD.
Prof Nevo joined the Department of BME in TAU as a faculty member in 2009.

Prof. Nevo’s research deals with problems in neuroscience and immunology, by the use of experiments and theoretical methods in biophysics and modelling.
Primary academic achievements include the development of the theory of Ecoimmunity that proposes a unique approach to the tissue-immune interaction, and the pioneering work on biomedical applications with portable MRI systems.

In 2010, Prof. Nevo co-founded & served as the first academic director of the President Peres' program for nurturing Israel's future scientists and inventors (now titled Odyssey) in Tel-Aviv University (later replicated to the other universities in Israel).
In 2015 he founded Lifegraph: a company that leads a technology for behavioral monitoring using passive sensing.

More info here.

Nikolaos Kehagias

Nikolaos Kehagias (first time in FET) is co-founder and chief technical officer of Nanotypos.

Dr. Kehagias obtained his Bachelor's degree in Physics from the Aristotle University in Thessaloniki, Greece.
He continued his studies in Essex University (UK) where he got his Masterb's degree in Physics of laser communications in 2003.
He obtained his Ph.D. from the Tyndall National Institute/ University Colleague of Cork (Ireland) in 2007 and has more than 15-years experience in advanced nano-manufacturing techniques.

Dr. Kehagias has pioneered and developed several imprinted based lithography techniques and he is author and co-author in more than 45 journal publications, has been an invited speaker in 7 summer schools and have given 15 lectures on nanofabrication and applications, participated in more than 130 international and national conferences and contributed his work to 2 book chapters. he is inventor in 2 patents.

Maria Farsari

 

   

 

    She is a Research Director at FORTH/IESL and the leader of the NLL group. Her research activities focus on laser-matter interactions and ultra-fast laser materials processing. The NLL group has extensive experience in the development of photopolymers and their 2D and 3D micro- and nanoprocessing using lasers. They are particularly active in the field of multiphoton polymerization, where they are one of the world leaders in the synthesis, processing and   characterization of 3D micro-and nanostructures for applications in photonics, metamaterials and biomedicine. Dr. Farsari has participated in many FP6, FP7 & H2020 European research projects, and national projects also. Her group consists of two post-doctoral research scientist, four PhD students,  three MSc students and two undergraduates. She has published 90 papers in refereed journals; she has received over 4200 citations (Google Scholar). Her h-index is 37.            

More info here.

Emanuela Jacchetti

Emanuela Jacchetti completed her Master Degree and Ph.D. in Physics at “Università degli Studi” in Milan.

She worked as Researcher in several Institutes and Centers of Excellence until 2015, when she arrived at Politecnico di Milano, where she currently is Assistant Professor.

Emanuela has a strong experience in the field of cell scaffold, mechanobiology, and fluorescence microscopy.

Her main interests are cell mechanics and nuclear mechanotransduction, governing cellular functions and tissue regeneration.

Claudio Conci

Claudio Conci obtained his M.Sc. in biomedical engineering in 2017 at Politecnico di Milano, Italy.

Here, he is currently attending a PhD program in bioengineering in collaboration with Prof. Roberto Osellame’s group at the IFN-CNR in Milano and Prof. Giberto Chirico’s group at Università degli Studi di Milano Bicocca.

His research focuses on nonlinear microscopy techniques applied in intravital conditions and on the development of implantable miniaturised imaging windows fabricated by two photon laser polymerization.

Maddalena Collini

Maddalena Collini graduated in Physics, PhD in Biophysics, is full professor of Applied Physics, University of Milano Bicocca, Dep. of Physics and Course Director of the Bachelor and the Master degree in physics and Astrophysics at the University of Milano Bicocca. MC is the PI of the Super-resolution microscope financed in 2011 by the Università di Milano-Bicocca.
Scientific background in time-resolved fluorescence spectroscopy techniques applied to the study of biosystems of different complexity. MC has a long experience in the application of fluorescence polarization anisotropy decay for detecting molecular diffusive motions in DNA or proteins. MC deeply applied fluorescence correlation spectroscopy in the photophysics characterizations of GFP mutants. MC has also applied fluorescence spectroscopy to study signaling or interactions in cells either employing FRET probes or calcium imaging. A parallel field of research also is devoted to characterize optical properties of nanoparticles and their cellular uptake exploiting their luminescence by nonlinear excitation. Since 2011, MC has been the PI of the super-resolution microscope based in STED (excited emission depletion ) technology that reaches image resolution of 60 nm as tested on single fluorescent molecules. Concerning the in vivo measurements, MC performs hemodynamics studies on model animal systems (Zebrafish embryos) in order to develop protocols of image analysis to be used in more complex systems. MC is member of American Biophysical Society and the Italian Society for Pure and Applied Biophysics, editor of PLOSONE, in the review panel of Current Medicinal Chemistry, author/co-author of more than 90 publications on scientific journals: H factor = 20, total citations 1677.

More info here.

Avner Priel

Avner Priel holds a PhD in Physics (complex systems) and is currently managing the “Cell Studio” project for inSilico agent-based modeling of immune response. His scientific background is in theoretical and experimental biophysics of the neuronal cytoskeleton, as well as neural computation. In parallel, he pursued extensive corporate experience in leading groups of researchers in the area of machine learning and A.I. applications to various industrial problems. A.P. has been a research associate in the department of Physics, University of Alberta, Canada, and the faculty of life-sciences in Bar-Ilan university, Israel. He is the author/co-author of more than 30 publications in scientific journals, book chapters and original manuscript titled Nanoneuroscience: Structural and Functional Roles of the Neuronal Cytoskeleton in Health and Disease, Springer-Verlag (2010), Nancy J. Woolf, Avner Priel and Jack A. Tuszynski.

More info here.

Lidia Canovas

LIDIA CANOVAS

first time FET participant.
Pharmacist. Specialist postgraduate degree qualification in Industrial Pharmacy and Galenic Formulation with a Master of Advanced Studies (MAS) in Biopharmacy, Pharmacology and Drug Quality. Specialist in drug development and in drug product development activities of new chemical drugs and biologics (including biosimilars and ATMPs). She has been for 4 years Vice-Director for Research and Development and 15 years as General Manager of Regulatory Affairs at ASPHALION. Responsible for the overall Quality of the Regulatory services of Asphalion. Experience in scientific medical writing of regulatory documents for CTAs, Scientific Advice Procedures, Orphan Drug Designations (EU and FDA). 

Addtional Info.

Marta Rayo Lunar

MARTA RAYO

first time FET participant.
Pharmacist and Specialist postgraduate degree qualification in Industrial Pharmacy and Galenic Formulation, with a Master of Advanced Studies (MAS) in Biopharmacy, Pharmacology and Drug Quality. He has 7 years of experience as R+D Project Manager at Spanish biotechnology company focused on the development of drug candidates and 2 years CMC Regulatory Affairs Specialist in drug development and in drug product development activities of new chemical drugs, biologics (including biosimilars and ATMPs) and nanodrugs. Marta ha experience in scientific medical writing of regulatory documents for CTAs, Scientific Advice Procedures, Orphan Drug Designations (EU and FDA), and clinical documentation (IMPD/IB).

More info here.

Christopher Mann

Christopher Mann

first time FET participant
Chrstopher holds a PhD in Biomedicine and a long academic research experience in gene therapy, regeneration and muscular dystrophy, diabetes. He has published numerous original research papers and review articles in peer reviewed journals. Expert in medical and scientific writing for Biosimilars, Innovative, Biological, Biotechnological, and Advanced Therapy Medicinal Products, including gene and somatic cell therapies. Currently working in medical writing for Paediatric Investigation Plans, Scientific Advice/Pre-IND meetings and Centralized Procedures. Experience in Biosimilars CP writing Clinical and Pre-Clinical. Worldwide experience in Biosimilars Gap Analysis and writing. Expert in medical and CMC scientific writing for Innovative, Biological, Biotechnological, and Advanced Therapy Medicinal Products, including gene and somatic cell therapies.

additional info here.

Thomas Zwingers

first time FET participant.
Thomas holds Master’s degree in Cybernetics from the Technical University of Munich. He belongs to numerous international associations including the International Society for Clinical Biostatistics and the Society for Clinical Trials and has written and collaborated on over 100 publications focusing on the pharmaceutical and clinical trial statistics. Thomas provides pharmaceutical, biotech and medical device companies with statistical methodology advice pertaining to trial design, conduct and reporting including regulatory submission. He has presented statistical findings to the European Medicines Agency on numerous occasions. Thomas has been working in the clinical trial environment since 1980 in project team management and statistical analysis. He specializes in statistical analysis and reporting with particular expertise in Adaptive Trial Design, Meta-Analysis and Non-Inferiority Trials. Prior to joining CROS NT, Thomas was an independent statistical consultant and ran his own biometrics consulting CRO in Germany for over 20 years. During this time, he gained a considerable amount of experience in Dermatology, Respiratory and Oncology studies. With regards to oncology studies, Thomas is an expert on both the complexities of early phase trial design and flexible designs of late phase studies such as the implementation of adaptive trial design. He has published articles and conducted courses and webinars on statistical considerations in oncology trials.

More info here.

Costas Kehagias

  First time participating in FET.
 

Costas is co-founder and Managing director of Nanotypos. He has a 20-year experience is management, marketing

and commercialization as he has been CEO of two Design &  Communication companies.

Mr. Costas Kehagias is responsible for all managing, administrative and public outreach activities.

Theodoros Tachtsidis

  First time participating in FET.
 

  Physicist, obtained his Bachelor’s degree from the Aristotle University in Thessaloniki, Greece.

  Since 2015 he is working as a research assistant engineer within Nanotypos while his work focuses

  on the development of security printing and functional surfaces by imprint-based processes

   (batch-to-batch and roll-to-roll) for tailored products & components.

Christina Argyropoulou

    First time participating in FET.
 

  Christina is Nanotypos project manager graduated in 2003 from the school of economics of the Aristotle University of

  Thessaloniki, Greece. In 2006, Mrs. Argyropoulou completed her MBA from the Bergische University of Wuppertal

  (Germany) while in 2015 she received her second master’s degree in Banking from the open University of Greece.

    Since 2008 she has been working in various private sectors as administrative and financial officer.

Laura D'Alfonso

Laura D’Alfonso graduated in Physics, PhD in Biophysics, is now associate professor of Applied Physics, University of Milano Bicocca, Dep. of Physics. The research activity of LD has mainly focused in molecular biophysics, and it has been devoted to the application of spectroscopic techniques to study the structural and dynamic properties of proteins, and to analyze their interaction, by combining experimental and theoretical-simulative approaches. Since 2001 LD collaborates to the development of a laboratory for advanced spectroscopy (LABS) where fluorescence techniques have been combined to non-linear optical microscopy to perform experiments at high spatial and temporal resolution on the stability of biomolecules and on their interactions, down to the single molecule level or in cells or tissues, for biological and medical applications. LD has acquired experience in time resolved fluorescence spectroscopy and in in-vitro and in-vivo single molecules fluorescence. Moreover, LD has acquired expertise on advanced fluorescence techniques by employing non-linear excitation to perform experiments of fluorescence correlation spectroscopy (FCS), fluorescence lifetime imaging (FLIM) and resonant energy transfer (FRET) in solutions and in cells.
Hot spots of LD’s research have been the investigation of the internal photodynamic of proteins, the development of nano-biosensors based on the lifetime changes of particular fluorophores, with several possible applications and the development of nanocomposite (metal nanoparticles/polymers) films for remote photo-thermal antibacterial and medic applications. LD is author/co-author of more than 65 publications on scientific journals, H factor=20, citations 1200.

More info here.

Laura Sironi

Laura Sironi graduated in Physics, PhD in Biophysics, is now Associate Professor of Applied Physics, University of Milano Bicocca, Dep. of Physics. LS has a scientific background in advanced spectroscopic methods and in fluorescence techniques combined to linear and nonlinear optical microscopy for biological and medical applications. LS has acquired expertise in time resolved fluorescence spectroscopy (both lifetime and anisotropy decay) in-vitro and in-vivo (cells), in fluorescence correlation spectroscopy (FCS), fluorescence lifetime imaging (FLIM) and resonant energy transfer (FRET) in solutions and in cells.
The research activity of LS is also devoted to the development of image analysis methods applied to data acquired by in-vivo and ex-vivo single and multi-photon excitation microscopy to extract cells dynamic/interaction parameters (cell tracking and morphology, host pathogen interactions in lymph nodes, study of the physical properties of tumor microenvironments) and hemodynamics in model and complex systems/organisms (microfluidic channels, zebrafish and hepatic microcirculation in mice). LS research interest is also focused on the study of the second harmonic signal generated by collagen in different tumour tissues (also by means of a novel phasor-based approach). Other topics of LS research are the characterization of optical and thermal properties of theranostic devices, based on gold/silver nanoparticles, and the study of their interaction with cells by means of image correlation spectroscopy techniques. LS is author/co-author of more than 40 publications on scientific journals; H factor = 17, citations = 900.

More info here.

Anthi Ranella

She is a Researcher at IESL-FORTH and leads the “Tissue Engineering – Regenerative Medicine and Immunoengineering Lab (TERMIM Lab). Her current fields of interests comprise mainly the study of the 3D scaffolds topology and chemical characteristics effect on specific cell responses such as adhesion, proliferation and differentiation. Dr. Ranella has entered into European (FP7 and Horizon 2020) and National research projects. In the interdisciplinary area of her interest three post-doctoral research scientists, three PhD, two MSc and two undergraduate students, originated from different scientific fields, are employed. Her research activities have led to the granting of two patents and have contributed in more than 45 publications in international peer-reviewed journals and 4 chapters in scientific books which have been cited over 1400 times (Scopus, h-indexr=18).

More info here.

Dimitris Papazoglou

   

He is Assist. Professor in the Department of Materials Science and Technology of the University of Crete and Associated Researcher at IESL-FORTH. He holds a B.Sc. in Physics (1991), an MSc in Radio-Electronics (1995) and a PhD in optical memories and information processing (1998) from the Aristotle University of Thessaloniki, Greece. His research focuses in the area of optics with emphasis on non-linear optics, ultrafast laser matter interaction phenomena, optical system design, and wavefront sensing and manipulation. The output of his research is presented in over 65 publications in peer reviewed journals, several talks at major international conferences and 2 chapters in books which have been cited over 2600 times (h-index=28). He has been involved in several EU and nationally funded research projects.

More info here.

Dimitris Papazoglou

   

She is currently a Post-Doctoral research fellow at FORTH/IESL. She is a PhD graduate from the Department of Physics of the University of St. Andrews in UK (2013) and she gained both her Bachelors (2007) and M.Sc. degrees (2009) with distinction from the Department of Physics of the University of Crete in Greece; where she undertook multiple projects in Laser Interaction and Division research area with a particular emphasis on Laser Beam Shaping, Nanotechnology, Laser Materials Processing, Materials Science and Bio-Photonics applications. Her Post-Doctoral research includes work for almost four years (2014-2018) as a Research & Development (R&D) Scientist to develop new methods of lithography in Nanoscribe GmbH (Karlsruhe, Germany) and work (2013-2014) as a Laser Development Engineer during the TwO Photon absorbers for BIOmedical applications (TOPBIO) project in Amplitude Systèmes (Bordeaux, France) funded by a Marie Skłodowska Curie Initial Training Network (ITN). Her research has been published in over 15 publications in peer reviewed journals and conference proceedings, reflecting in more than 520 citations and her H-index is 9, according to Google Scholar.

Elmina Kabouraki

   

She is a Post Doctoral fellow at FORTH/IESL. She received her and Master and PhD (2019) degree from the Materials Science and Techology Department of Universty of Crete, Greece. Dr. Kabouraki specializes in the synthesis and characterization of hybrid photosensitive materials, synthesis and characterization of quantum dots and the fabrication of three-dimensional photonic devices via the multi-photon polymerization technique. In her PhD thesis she was involved in the synthesis of novel photosensitive materials and in the fabrication of optical switching devices as well as three-dimensional photonic crystal lasers. She is the author of 6 peer-reviewed publicationsand and of a book chapter in non-liner optics. She has participated in numerous international conferences and she has received the best presentation prize for PhD student at the European Materials Research Symposium.

Apostolos Dimitriadis

  First time participating in FET.
 

He is the Head of Business Development Unit & FORTH Technology Transfer Office at PRAXI Network. He is responsible for the design of services, activities and the daily operation of both Units and the management of resources. Prior to this position, Apostolos was the coordinator of the NCP team of PRAXI and the Technical Coordinator of CIP-Hellas. He has worked as an expert for the creation and promotion of national and regional development policies. Apostolos holds a degree in Physics from the Aristotle University of Thessaloniki, Greece and an MSc and a PhD in Theoretical Physics from the University of Durham, UK. Prior to joining PRAXI Network Apostolos was working as a post-doctoral researcher at the University of Ioannina, Greece. He conducted research on several aspects of Theoretical Physics and assisted in the training of two PhD students.

Additional info here. 

Maria Makridaki

   

   

 

She is a Technology Transfer Consultant at PRAXI Network. Her activities involve IPR management, access to public and private funding, exploitation of research results and provision of information and advisory services to all stages of technology transfer. She has coached several research teams on exploiting their research results. She is actively involved in the creation and promotion of regional development policies and the implementation of Smart Specialisation Strategies. She is an appointed Horizon 2020 National Contact Point for Nanotechnologies, Advanced Materials, Biotechnology, and Advanced Manufacturing and Processing. She holds a degree in Physics from the University of Crete, an MSc in Optics and Vision from the University of Crete and a PhD in Visual Neurosciences from the University of Manchester, UK. She investigated visual abnormalities in Age Related Macular Degeneration and has experience in designing, running and monitoring clinical studies. She worked as a research assistant at the University of Manchester and as a sales and scientific consultant for Topcon Medical Instruments Ltd.

 

Additional info here. 

Biocompatibility tests

   

Credits. 

 

   

 

The development of new implantable medical devices needs certification by a notified body (according to Regulation (EU) 2017/745 on Medical Devices) and the assessment of the material biocompatibility profile according to the ISO 10993 series. All these norms result in lengthy, expensive, inefficient, complex and partly subjective studies.IN2SIGHT will be a revolutionary technological platform that will reduce costs and increase the efficacy of regulatory standards by improving statistical significance of the data and complying with relevant formats for data exchange (SEND) and GLP.

References:

1. S. Ramakrishna, L. Tian, C. Wang, S. Liao, W-E Teo. "Safety testing of a new medical device", 
   Medical Devices, 2015,137-153, DOI.

 

Alexandros Selimis

Additional info here. 

Mario Marini

young man casual avatar vector illustration design

Additional info here. 

Margaux Bouzin

Additional info here. 

Analysis of the host inflammatory response

The cytocompatibility of the biomaterial in vitro and the immunogenicity in vivo are tested in general following these lines of actions.

• Cytocompatibility in vitro is tested on immortalized cell lines, using metabolic assays and imaging and looking how cells differentiate in the presence of the materials.
• In vivo immunogenic evaluations track cellular viability and activation. For viability, the morphology and number of immune cells populating the biomaterial surface is checked with staining protocols and/or by metabolic assays. Cell activation tests detect pro- and anti-inflammation cell surface markers through immunohistochemistry, immunofluorescence or FACS.

However, in vitro tests lack a full inflammatory environment and in vivo tests are ethically undesirable.

The project IN2SIGHT aims to renovate the methods for the validation of biomaterials by improving and renovating the statistical methods to analyse the data on the immune response and dramatically reduce the ethical impact of the research.

Consortium as a whole

The academic/research and the industrial partners come from 5 countries and are:

• Università degli studi di Milano-Bicocca (UNIMIB), Milano (I)
• Politecnico di Milano (POLIMI), Milano (I)
• Deutsches Krebsforschungszentrum (DKFZ), Heidelberg (D)
• Institute for elecotrnics and Laser Science (FORTH-IELS) and Praxi Network, Crete (GR)
• Tel Aviv University (TAU), Tel Aviv (IL)
• Asphalion (ASPHALION), Barcelona (E)
• Nanotypos (NANO), Thessaloniki (GR)

They form 3 transversal working units with unique knowledge and skills in

1. material science (FORTH), 2PP laser printing (POLIMI), optical in vivo imaging, animal surgery (UNIMIB), vascularization (DKFZ) and production and replication of micro/nano structured surfaces (NANO);
2. in vitro (POLIMI) and in vivo validation (UNIMIB) of the immune response to implants;
3. development of materials for medical implants (POLIMI) and in biomaterial validation (ASPH and TAU).

The capability of synergy between all partners is proved by existing common publications, European projects (ENCITE,  NICHOID) and academic agreements for R&D between partners. The R&D success is based on correlated and sequential actions between all the partners from the in vitro validation of the device to the in vivo implementation of the new regulation protocols.